The Association between malignant disorders of White Blood Cells and Bone Marrow Depression
Bone marrow depression is associated with malignant disorders of white blood cells. Bone marrow depression is a condition where hematopoietic cells decrease significantly. The decrease may be linked to reduced production of the hematopoietic cells. Hematopoietic stem cells (stem cells) that are likely to be diminished in cases of bone marrow depression develop into essential organs, including red blood cells and white blood cells. Significantly reduced numbers of stem cells, which are linked to bone marrow depression, affects the normal production of white blood cells. It is important to note that the stem cells eventually develop into white blood cells (Cook, 2018).
Malignant disorders of white blood cells can imply higher than normal production of white blood cells, or lower than normal production of white blood cases. In some cases, the bone marrow releases immature white blood cells as a consequence of cancers. Bone marrow depression directly influences a decrease in the hematopoietic stem cells that eventually develop into white blood cells. A decrease in white blood cells to less than 4000 cells per microliter of blood, or Leukopenia, is linked to low amounts of stem cells that occur in cases of bone marrow depression (Territo, 2020). People with bone marrow depression are at higher risk of succumbing to infection due to malignant disorders of white blood cells; this further the relationship to malignant disorders of white blood cells
References
Cook, J. R. (2018). Bone Marrow Failure Syndromes. In Hematopathology (pp. 167-183). Content Repository Only!.
Territo, M. (2020 Jan). Overview of white blood cell disorders. MSD MANUAL. Retrieved from https://www.msdmanuals.com/home/blood-disorders/white-blood-cell-disorders/overview-of-white-blood-cell-disorders